Genetic Analysis of Familial Mediterranean Fever among Egyptian Patients

Background: Familial Mediterranean fever (FMF) is an autoinflammatory genetic disorder that associated with different mutations. Frequency of clinical manifestation differs according to age group, geographic region and ethnic population. Objectives: To study the FMF in relation genotype (M680I, M694V, M694I V726A). Result: The main presentation studied group was abdominal pain 65.9% (203), followed by 60.4% (186) patients. (Mutation M694V) commonest 47.6% (297), V726A) 32.8% (169%), then M6802) 23.4% (121) lastly M6941) 22.1% (114) Fever highly mutation (V729A) it statistically significant (*p value 0.047). Conclusion: Abdominal were most common M694V), detected mutation. Third group; (V726A), (M6941).